[PATHO-L] Unusual tumor. Have you seen anything like this before?

John Butts jbutts at ocme.unc.edu
Wed Nov 23 05:17:23 MST 2011

Or a large red tattoo downstream?

On 11/23/2011 6:01 AM, Bob Richmond wrote:
> Was any history available? Is it possible that red stuff is foreign
> material? Might she have undergone a breast augmentation procedure in
> Elbonia?
> Bob Richmond
> Samurai Pathologist
> Knoxville TN
> ************************************************
> On Tue, Nov 22, 2011 at 9:45 PM, Jerad Gardner<zao275 at gmail.com>  wrote:
>> Dear Patho-L,
>> I need your help.
>> Last year during my fellowship with Sharon Weiss, we saw a very unusual
>> tumor from the axilla of a middle aged woman. It appears to be an unusual
>> liposarcoma that defies classification. In addition to having lipoblasts,
>> it has numerous round to spindled cells with abundant cytoplasm that is
>> filled with brightly eosinophilic rod-shaped crystals. The tumor was
>> negative for our usual panel of immunostains, and it was negative for MDM2
>> gene amplification (and FUS gene rearrangement) by FISH. Neither Sharon
>> Weiss nor Mark Edgar recall having seen a tumor with these particular
>> features before. I also sent recuts to several of Sharon's former soft
>> tissue fellows, none of whom had seen a tumor like this. I believe this is
>> a morphologically unique variant of liposarcoma (perhaps representing a
>> previously undescribed entity). I am eager to write this up for
>> publication, but Sharon said that I need to find at least one other example
>> of a tumor with similar features.
>> That is where all of you come in. I am hoping that this tumor will ring a
>> bell with at least one of you who has seen something similar before (or
>> perhaps in the future). If you have seen something like this, please
>> contact me so that we can write it up. Photos are available on my Flickr
>> account: http://www.flickr.com/photos/jmgardnermd/sets/72157628105110001/.
>> Thanks very much for your help. Have a very happy Thanksgiving!
>> Jerad
>> *-------------------------------*
>> *Jerad M. Gardner, MD*
>> *Immediate Past Chair, CAP Residents Forum*
>> *Fellow, Dermatopathology, Emory University*
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